67 | id == 67
67 | category_id == 6
67 | category_order == 4
67 | category_name == Thyroid
67 | category_color == #C47AC0
67 | slug == TSHR-Thyroid-Health
67 | title == What’s the Link Between This Gene and Thyroid Autoimmunity? (TSHR)
67 | meta_description == Certain TSHR variants may be associated with higher rates of Graves' disease. Click here to learn more and check your genes!
67 | summary == <p style="text-align:justify"><strong><em>TSHR</em> is an essential genetic factor of thyroid health. Certain variants in this gene may be associated with higher rates of Graves&#39; disease. Read on to learn more and get personalized tips to support the thyroid!</strong></p>
67 | overall_score_text == Thyroid Score (based on TSHR)
67 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/TSHR_Thyroid_post_image.jpg
67 | author_id == 9
67 | author_name == Aleksa Ristic
67 | author_title == MS (Pharmacy)
67 | author_order == 45
67 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
67 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
67 | reviewer_id == 4
67 | reviewer_name == Matt Carland
67 | reviewer_title == PhD
67 | medical_reviewer_id == 11
67 | medical_reviewer_name == Puya Yazdi
67 | medical_reviewer_title == MD
67 | publish_date == 2019
67 | publish_date == 10
67 | publish_date == 31
67 | avg_rating == 5.0
67 | tags_id == 33
67 | tags_name == Autoimmunity
67 | tags_id == 83
67 | tags_name == Grave's Disease
67 | tags_id == 41
67 | tags_name == Thyroid
67 | tags_id == 205
67 | tags_name == TSH
67 | tags_id == 204
67 | tags_name == TSHR Gene
67 | permissions_favorite == False
67 | permissions_rate == False
67 | content_article == <h2 style="text-align: justify;"><strong><em>TSHR</em> and Thyroid Health</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The pituitary gland makes </span><a href="https://www.selfhacked.com/blog/thyroid-stimulating-hormone/"><span style="font-weight: 400;">TSH</span></a><span style="font-weight: 400;"> (</span><em><span style="font-weight: 400;">thyroid-stimulating hormone</span></em><span style="font-weight: 400;">, or "</span><em><span style="font-weight: 400;">thyrotropin</span></em><span style="font-weight: 400;">"), whose primary purpose is to stimulate the thyroid gland to produce several important </span><a href="https://selfhacked.com/blog/thyroid-hormones-t4t3/"><span style="font-weight: 400;">thyroid hormones</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19179434/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/books/NBK278958/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="../../gene/tshr/"><em><span style="font-weight: 400;">TSHR</span></em><span style="font-weight: 400;"> gene</span></a><span style="font-weight: 400;"> codes for </span><strong>TSH </strong><strong>r</strong><strong>eceptors ("TSHRs")</strong><span style="font-weight: 400;"> on thyroid cells, enabling them to be stimulated by the pituitary gland. Thus, </span><em><span style="font-weight: 400;">TSHR</span></em><span style="font-weight: 400;"> is one of the key players in thyroid health [</span><a href="https://ghr.nlm.nih.gov/gene/TSHR"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><strong><img style="display: block; margin-left: auto; margin-right: auto;" src="https://media.springernature.com/original/springer-static/image/chp%3A10.1007%2F978-1-4939-3737-0_5/MediaObjects/311199_1_En_5_Fig1_HTML.gif" alt="" /></strong></p> <p style="text-align: center;"><span style="font-weight: 400;">Image source: [<a href="https://link.springer.com/chapter/10.1007/978-1-4939-3737-0_5">R</a>]</span></p> <h3 style="text-align: justify;"><strong>The Role of <em>TSHR</em> in Graves&rsquo; Disease</strong></h3> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/graves-disease/"><span style="font-weight: 400;">Graves&rsquo; disease</span></a><span style="font-weight: 400;"> (GD) is an autoimmune condition in which antibodies from the immune system mimic TSH and activate TSH receptors, resulting in the overproduction of thyroid hormones. This can lead to enlargement of the thyroid gland, as well as symptoms such as [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271308/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26670972"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">Fatigue</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/natural-treatments-anxiety/"><span style="font-weight: 400;">Anxiety</span></a></li> <li style="font-weight: 400;"><a href="http://selfhacked.com/blog/a-comprehensive-list-of-effective-ways-to-lose-weight/"><span style="font-weight: 400;">Weight Loss</span></a></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Eye pain, redness, and swelling</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Increased </span><a href="https://www.selfhacked.com/blog/resting-heart-rate/"><span style="font-weight: 400;">heart rate</span></a></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Shaky hands</span></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">These <em>TSHR-stimulating antibodies</em> (TSAbs) are the hallmark sign of Graves' disease, which are present in nearly all cases. Their levels often correlate with the severity of the disease. Since the <em>TSHR</em> gene determines the number and structure of TSH receptors, it essentially controls how sensitive the thyroid gland is to (over-)stimulation. Therefore, experts consider this gene to be among the main genetic factors involved in GD [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128637/">R</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/23529038/">R</a>].</span></p> <h2 style="text-align: justify;"><strong><em>TSHR</em> Variants That Correlate With Graves&rsquo; Disease</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The role of </span><em><span style="font-weight: 400;">TSHR</span></em><span style="font-weight: 400;"> in Graves' disease has been a hot topic for several decades, but it wasn&rsquo;t until 2016 that researchers established a firm connection. A meta-analysis of eight clinical trials with over 14,000 participants confirmed two major variants that are associated with the development of GD [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138578/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><a href="../../snp/rs179247/"><span style="font-weight: 400;">rs179247</span></a><span style="font-weight: 400;"> (A/G): The major &ldquo;A&rdquo; allele is associated with 42% higher rates of GD</span></li> <li style="font-weight: 400;"><a href="../../snp/rs12101255/"><span style="font-weight: 400;">rs12101255</span></a><span style="font-weight: 400;"> (C/T): The minor &ldquo;T&rdquo; allele is associated with 50% higher rates of GD</span></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">Another group of authors also conducted a meta-analysis that further confirmed these findings [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27465319"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">According to one clinical study, GD patients with the &ldquo;AA&rdquo; genotype for rs179247 get Graves' disease on average 9.2 years earlier, compared with carriers of the &ldquo;GG&rdquo; genotype [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21642385"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">A recent trial of 1,200 participants identified two more </span><em><span style="font-weight: 400;">TSHR</span></em><span style="font-weight: 400;"> variants with a significant impact: the major &lsquo;G&rsquo; allele of </span><a href="../../snp/rs4903964/"><span style="font-weight: 400;">rs4903964</span></a><span style="font-weight: 400;"> and the major &lsquo;C&rsquo; allele of </span><a href="../../snp/rs12101261/"><span style="font-weight: 400;">rs12101261</span></a><span style="font-weight: 400;"> have each been associated with </span><em><span style="font-weight: 400;">lower</span></em><span style="font-weight: 400;"> rates of Graves' disease [</span><a href="https://www.hindawi.com/journals/ijg/2019/6982623/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Specific <em>TSHR</em> variants &mdash; such as rs179247-A, rs12101255-T, and rs12101261-T &mdash; have been associated with Graves' disease and other thyroid disorders.</span></p> <h3 style="text-align: justify;"><strong>How It Works</strong></h3> <p style="text-align: justify;"><span style="font-weight: 400;">Scientists are still figuring out the exact mechanisms responsible for the associations between these </span><em><span style="font-weight: 400;">TSHR</span></em><span style="font-weight: 400;"> variants and thyroid disorders. According to some researchers, one part of the answer may lie in the potential of these variants to change the TSH receptor structure and stimulate an autoimmune response against it [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138578/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271308/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">For example, several researchers have suggested that these variants may reduce the length of one part of the TSH receptor (called the </span><em><span style="font-weight: 400;">alpha subunit</span></em><span style="font-weight: 400;">), which tricks the immune system into &ldquo;attacking&rdquo; the receptor [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19244275"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/12813025/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20083159"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Different studies have analyzed blood samples of GD patients, and have identified two changes in the immune system that may mediate this &ldquo;self-attack&rdquo; [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708941/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702927/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27855396"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24443787"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">Increased </span><a href="http://selfhacked.com/blog/supplements-people-th1-dominant/"><span style="font-weight: 400;">Th1</span></a><a href="http://selfhacked.com/blog/th17/"><span style="font-weight: 400;">7</span></a><span style="font-weight: 400;"> cells and </span><a href="http://selfhacked.com/blog/interleukin-1/"><span style="font-weight: 400;">IL-1</span></a><a href="http://selfhacked.com/blog/th17/"><span style="font-weight: 400;">7</span></a><span style="font-weight: 400;"> production</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Lowered </span><a href="http://selfhacked.com/blog/treg/"><span style="font-weight: 400;">T-regs</span></a><span style="font-weight: 400;"> (regulatory T cells)</span></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">According to some authors, another possibility is that the variants prevent immune cells from building tolerance to TSHRs, which could result in autoimmunity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21642385"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151767/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em>TSHR</em> variants probably change the structure of TSH receptors and <span style="font-weight: 400;">prevent immune cells from building tolerance to them</span>. This effect may increase Th17 cells and decrease T-regs, leading to an autoimmune response.</span></p> <h2 style="text-align: justify;"><strong>Your <em>TSHR</em> Results for Graves' Disease</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">You can see your genotype for several <em>TSHR</em> SNPs in the table below. However, it is important to keep in mind that these results are based on association studies suggesting that certain genetic variants are relatively more common in people with thyroid conditions. More research will be needed to know what role, if any, these variants play in directly <em>causing</em> thyroid issues. Therefore, just because you have one of these genotypes does not necessarily mean you are at increased risk of developing any of these health conditions!</span></p> <p style="text-align: justify;"><strong>*6487491221862807*</strong></p> <p style="text-align: justify;"><strong>Primary SNPs:</strong></p> <p style="text-align: justify;"><em><strong>TSHR </strong></em><a href="../../snp/rs179247/"><strong>rs179247</strong></a><strong>:</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with higher rates of Graves' disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with Graves' disease</span></li> </ul> <p style="text-align: justify;"><em><strong>TSHR </strong></em><a href="../../snp/rs12101255/"><strong>rs12101255</strong></a><strong>:</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with higher rates of Graves' disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with Graves' disease</span></li> </ul> <p style="text-align: justify;"><em><strong>TSHR </strong></em><a href="../../snp/rs12101261/"><strong>rs12101261</strong></a><strong>:</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with lower rates of Graves' disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with Graves' disease</span></li> </ul> <p style="text-align: justify;"><em><strong>TSHR </strong></em><a href="../../snp/rs4903964/"><strong>rs4903964</strong></a><strong>:</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with lower rates of Graves' disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with Graves' disease</span></li> </ul> <h3 style="text-align: justify;"><strong>Population Frequency</strong></h3> <p>These four SNPs are almost always inherited together, so they act as a single genetic factor. This means most people either have no "problematic" alleles or all of them. About 45% of European descendants carry one and 10% carry both copies of problematic alleles. In East Asian populations, about 35% of people have both copies.&nbsp;</p> <p>The "problematic" allele at rs179247 is a bit more common in Europeans, with both copies present in 25% of people.</p> <p style="text-align: justify;"><strong>*1301107550444502*</strong></p> <h2 style="text-align: justify;"><strong>Strategies to Improve Thyroid Health</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">There isn&rsquo;t a known way to prevent Graves' disease, but your doctor can successfully treat it with medications once diagnosed. Therefore, if you&rsquo;re experiencing symptoms of Graves' disease &mdash; such as sudden weight loss, increased heart rate, sweating, and shaky hands &mdash; it is important to consult with your doctor ASAP to ensure you get adequate medical care.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Your doctor may suggest adding the complementary approaches mentioned below &mdash; but they should not be used to replace conventional medical treatment.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In the following sections, we&rsquo;ll detail some lifestyle, diet, and supplement choices that may help alongside medical treatment.</span></p> <p style="text-align: justify;"><strong>*3695234807456082*</strong></p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h5 style="text-align: justify;"><strong>Avoid Cigarette Smoke</strong></h5> <p style="text-align: justify;"><span style="font-weight: 400;">Extensive research has documented the adverse effects of cigarette smoking on the immune system. It can stimulate Th17 cells and suppress T-regs, potentially worsening the impact of </span><em><span style="font-weight: 400;">TSHR</span></em><span style="font-weight: 400;"> variants [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868633/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361762/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In fact, smoking has been associated with a 2x higher risk of Graves' disease and a 3-4x higher risk of Graves' ophthalmopathy (thyroid eye disease); it also raises the risk of GD recurrence in people who have already developed the disease [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11331213/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21142817/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Therefore, refrain from smoking to support your thyroid and improve overall health. And keep in mind that merely being around people who smoke &mdash; also known as &ldquo;second-hand&rdquo; or &ldquo;passive&rdquo; smoking &mdash; can be a significant source of exposure, too!</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Smoking stimulates Th17 cells, suppresses T-regs, and doubles the risk of Graves' disease. Refrain from smoking and avoid passive smoke to improve your thyroid health.</span></p> <h5 style="text-align: justify;"><strong>Get More Sunlight</strong></h5> <p style="text-align: justify;"><span style="font-weight: 400;">Some research has suggested that </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">UV light</span></a><span style="font-weight: 400;"> and vitamin D may boost T-regs and reduce Th17, which could potentially help counteract the effects of </span><em><span style="font-weight: 400;">TSHR</span></em><span style="font-weight: 400;"> variants [</span><a href="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0054895"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626364/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047889/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371662/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/8760564"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Sensible </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">sun exposure</span></a><span style="font-weight: 400;"> is the best way to get natural UV light and vitamin D. More sunlight during the day may also improve your </span><a href="http://selfhacked.com/blog/what-it-means-to-keep-to-a-circadian-rhythm/"><span style="font-weight: 400;">circadian rhythm</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/health-benefits-sleep/"><span style="font-weight: 400;">sleep quality</span></a><span style="font-weight: 400;">, which are each essential for maintaining thyroid health [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/2105332/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/8827131"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.sciencedirect.com/science/article/pii/B9781416066453000268"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">That said, spending more time in the sun increases the risk of skin damage &mdash; so make sure to find the right balance and avoid getting sunburns [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730532/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">By providing natural UV light and vitamin D, sun exposure may re-balance the immune system and support the thyroid. However, be careful not to get sunburns and damage the skin!</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <p style="text-align: justify;"><em><span style="text-decoration: underline;">Important</span>:<span style="font-weight: 400;"> Nutritional and herbal supplements can be a significant source of dietary iodine &mdash; even if it&rsquo;s not listed on the label &mdash; which is something people with thyroid issues are often advised to avoid. Therefore, be sure to talk to your doctor before starting any new supplements.</span></em></p> <p style="text-align: justify;"><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">Vitamin D</span></a><span style="font-weight: 400;"> supplements can be a useful way to correct a vitamin deficiency due to inadequate sun exposure or other factors [</span><a href="https://www.ncbi.nlm.nih.gov/books/NBK532266/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">According to a meta-analysis of 26 clinical trials, Graves' disease patients are 2.2 times more likely to have a vitamin D deficiency [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446781/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Vitamin D supplementation lowered thyroid volume and improved eye health in a study of 60 GD patients. However, before we draw any solid conclusions, larger clinical trials will be needed to confirm this effect of vitamin D [</span><a href="http://www.esim.eg.net/article.asp?issn=1110-7782;year=2017;volume=29;issue=2;spage=64;epage=70;aulast=Sheriba;type=0"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Supplements may help correct vitamin D deficiencies, which may be up to twice as common among Graves' disease patients.</span></p>
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67 | content_learn_more_1301107550444502_text == Your TSHR variants correlate with slightly higher rates of Graves' disease. Still, many other genetic and environmental factors influence thyroid health. This post reveals natural strategies that may help re-balance the immune system and support the thyroid — keep reading for more details!
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rsIDs = rs179247,rs4903964,rs12101261,rs12101255
rsStatus = rs179247,TSHR,chr14,80966202,A,G,,,17,11,HET
rsStatus = rs4903964,TSHR,chr14,81002610,G,A,C,T,16,8,HET
rsStatus = rs12101261,TSHR,chr14,80984885,C,T,,,21,11,HET
rsStatus = rs12101255,TSHR,chr14,80984708,C,T,,,24,11,HET
