83 | id == 83
83 | category_id == 6
83 | category_order == 4
83 | category_name == Thyroid
83 | category_color == #C47AC0
83 | slug == CAPZB-thyroid-health
83 | title == How a Cell Structure Gene Impacts Thyroid Health (CAPZB)
83 | meta_description == The CAPZB gene controls the formation of cell  “skeleton”. Click to learn how variants in this gene impact thyroid health.
83 | summary == <p style="text-align:justify"><strong><em>CAPZB</em>, a gene that controls the formation of &ldquo;skeleton&rdquo; in your cells, impacts thyroid health in a surprising way. Click to learn the effects of five different CAPZB variants!</strong></p>
83 | overall_score_text == Your overall thyroid score (based on CAPZB gene)
83 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/7daf628e.jpg
83 | author_id == 9
83 | author_name == Aleksa Ristic
83 | author_title == MS (Pharmacy)
83 | author_order == 45
83 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
83 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
83 | reviewer == None
83 | medical_reviewer_id == 11
83 | medical_reviewer_name == Puya Yazdi
83 | medical_reviewer_title == MD
83 | publish_date == 2020
83 | publish_date == 1
83 | publish_date == 23
83 | avg_rating == 5.0
83 | tags_id == 228
83 | tags_name == Actin
83 | tags_id == 45
83 | tags_name == cAMP
83 | tags_id == 229
83 | tags_name == CAPZB Gene
83 | tags_id == 227
83 | tags_name == Goiter
83 | tags_id == 43
83 | tags_name == Hypothyroidism
83 | tags_id == 113
83 | tags_name == T3
83 | tags_id == 41
83 | tags_name == Thyroid
83 | tags_id == 205
83 | tags_name == TSH
83 | permissions_favorite == False
83 | permissions_rate == False
83 | content_article == <h2><strong>The Link Between CAPZB and the Thyroid</strong></h2> <p><img src="https://ghr.nlm.nih.gov/art/large/actin.jpeg" alt="Actin Subunit and Actin Filament" width="600" height="480" /></p> <p><sub><span style="font-weight: 400;">Source: <a href="https://ghr.nlm.nih.gov/art/large/actin.jpeg" target="_blank" rel="noopener">https://ghr.nlm.nih.gov/art/large/actin.jpeg</a>&nbsp;</span></sub></p> <p><span style="font-weight: 400;">The story of </span><a href="../../gene/capzb/"><span style="font-weight: 400;">CAPZB</span></a><span style="font-weight: 400;"> (capping actin protein of muscle Z-line subunit beta) begins in a cell skeleton.</span></p> <p><span style="font-weight: 400;">Actin filaments are globe-shaped proteins that bind together to form a complex structure (helix), providing our cells with a backbone or skeleton. </span><em><span style="font-weight: 400;">CAPZB</span></em><span style="font-weight: 400;"> encodes for a protein that binds to actin polymers and impacts their formation. More precisely, it caps the ends of these filaments, preventing their elongation, hence &ldquo;capping actin protein&rdquo; [</span><a href="https://www.ncbi.nlm.nih.gov/gene/832"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">This process changes cell structure and controls different pathways, including </span><a href="https://selfhacked.com/blog/hypothyroidism-may-good-autoimmunity/"><span style="font-weight: 400;">thyroid function</span></a><span style="font-weight: 400;">. In response to </span><a href="https://www.selfhacked.com/blog/thyroid-stimulating-hormone/"><span style="font-weight: 400;">TSH</span></a><span style="font-weight: 400;">, thyroid cells open up to ingest the colloid from their surrounding and supply </span><a href="https://selfhacked.com/blog/thyroglobulin/"><span style="font-weight: 400;">thyroglobulin</span></a><span style="font-weight: 400;">. This step, enabled and controlled by actin polymers, is essential for </span><a href="https://selfhacked.com/blog/thyroid-hormones-t4t3/"><span style="font-weight: 400;">thyroid hormones</span></a><span style="font-weight: 400;"> (T3/T4) production [</span><a href="https://www.ncbi.nlm.nih.gov/books/NBK28/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146733/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Another vital mediator in this chain reaction is cAMP, which enables adequate thyroid stimulation by TSH and plays a central role in the shape and function of thyroid cells. According to different cell-based studies, cAMP modulates the activity of CapZ proteins [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9165017/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15845376"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15845376"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">CAPZB encodes for a protein that changes cell structure by capping actin filaments. In thyroid cells, this cAMP-dependent process impacts the production of thyroid hormones by controlling the uptake of thyroglobulin.</span></p> <h2><strong>CAPZB Variants and Thyroid Function</strong></h2> <h3><strong>Hypothyroidism</strong></h3> <p><span style="font-weight: 400;">In a clinical trial of nearly 40K participants, one CAPZB SNP showed a suggestive association with low thyroid hormones. Namely, people with the &ldquo;C&rdquo; allele at </span><a href="../../snp/rs1472565/"><span style="font-weight: 400;">rs1472565</span></a><span style="font-weight: 400;"> had 11% higher rates of hypothyroidism [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321023/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>TSH Levels</strong></h3> <p><span style="font-weight: 400;">Different CAPZB variants have shown a significant correlation with TSH, a key marker of thyroid health:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">In a meta-analysis of 2 studies and over 26K participants, the &ldquo;A&rdquo; allele at </span><a href="../../snp/rs10799824/"><span style="font-weight: 400;">rs10799824</span></a><span style="font-weight: 400;"> correlated with lower TSH levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567175/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">In a meta-analysis that included 3,736 European subjects, the &ldquo;A&rdquo; allele at </span><a href="../../snp/rs10917477/"><span style="font-weight: 400;">rs10917477</span></a><span style="font-weight: 400;"> correlated with lower TSH levels [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22494929"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">In over 3,000 UK subjects, the &ldquo;G&rdquo; allele at </span><a href="../../snp/rs10917469/"><span style="font-weight: 400;">rs10917469</span></a><span style="font-weight: 400;"> correlated with lower TSH levels. People with the "GG" genotype had 0.5 mU/L lower levels, which can be a clinically significant difference [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933351/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><span style="font-weight: 400;">We&rsquo;ll discuss the potential mechanism behind these connections and their clinical relevance in more detail below.</span></p> <h3><strong>Goiter</strong></h3> <p><span style="font-weight: 400;">Goiter is a visible thyroid gland enlargement that can indicate both hypo- and hyperthyroidism. In nearly 5,000 participants of Caucasian (European) ancestry, different CAPZB SNPs correlated with thyroid volume and goiter. The main one is </span><a href="../../snp/rs12138950/"><span style="font-weight: 400;">rs12138950</span></a><span style="font-weight: 400;">, for which the carriers of the &ldquo;C&rdquo; allele had higher thyroid volume and higher rates of goiter [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146733/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>Potential Mechanisms and Clinical Relevance</strong></h3> <p><span style="font-weight: 400;">The exact mechanisms behind CAPZB variants and their clinical relevance for thyroid health are not fully understood, but the above study on goiter provides some valuable insights.</span></p> <p><span style="font-weight: 400;">Based on its position and physiological effects, the main observed SNP, </span><a href="../../snp/rs12138950/"><span style="font-weight: 400;">rs12138950</span></a><span style="font-weight: 400;">, likely increases CAPZB expression. According to the authors, this leads to the stronger capping of actin filaments and reduces the ability of thyroid cells to ingest thyroglobulin in response to TSH/cAMP stimulation. This results in diminished T3/T4 release and a compensatory increase in thyroid volume (goiter) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146733/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Interestingly, the authors discovered that the variants associated with goiter match those associated with lower TSH levels, and they are almost always inherited together. As it turns out, the compensatory increase in thyroid volume and hormone production results in lower TSH levels (negative feedback loop) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146733/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In other words, low TSH levels may indicate a hindered production of thyroid hormones in this case, which is the opposite of a standard interpretation. Still, we should take the suggested mechanisms with a grain of salt until more research is done on the subject.&nbsp;</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The above CAPZB variants likely increase its expression and the capping of actin filaments. This may result in impaired thyroid hormone production and compensatory thyroid enlargement (goiter). The suggested mechanisms are yet to be confirmed.</span></p> <h2><strong>Your CAPZB Results for Thyroid Health</strong></h2> <p><em><span style="font-weight: 400;">Keep in mind that the clinical relevance of most CAPZB SNPs is still not fully clear. Do additional tests and consult with your doctor before taking any action based on your results for this gene.</span></em></p> <p><strong>*5253543460890477*</strong></p> <p><strong>*5412265238616791*</strong></p> <p><strong>Primary SNPs:</strong></p> <p><strong><em>CAPZB</em></strong> <a href="../../snp/rs1472565/"><strong>rs1472565</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;T&rdquo; doesn&rsquo;t correlate with low thyroid hormones</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;C&rdquo; weakly correlates with low thyroid hormones</span></li> </ul> <p><strong><em>CAPZB </em></strong><a href="../../snp/rs12138950/"><strong>rs12138950</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;A&rdquo; doesn&rsquo;t correlate with goiter</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;C&rdquo; correlates with goiter</span></li> </ul> <p><strong>Other important SNPs:</strong></p> <p><strong><em>CAPZB </em></strong><a href="../../snp/rs10799824/"><strong>rs10799824</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;G&rdquo; doesn&rsquo;t correlate with TSH levels</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;A&rdquo; correlates with lower TSH levels</span></li> </ul> <p><strong><em>CAPZB </em></strong><a href="../../snp/rs10917477/"><strong>rs10917477</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;G&rdquo; doesn&rsquo;t correlate with TSH levels</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;A&rdquo; correlates with lower TSH levels</span></li> </ul> <p><strong><em>CAPZB </em></strong><a href="../../snp/rs10917469/"><strong>rs10917469</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;A&rdquo; doesn&rsquo;t correlate with TSH levels</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;G&rdquo; correlates with lower TSH levels</span></li> </ul> <h3><strong>Population Frequency</strong></h3> <p><span style="font-weight: 400;">For rs1472565, around 72% of European descendants carry the &ldquo;problematic&rdquo; C allele. The frequency of this allele in other populations is even higher.</span></p> <p><span style="font-weight: 400;">Two of the other SNPs, rs10799824 and rs10917469, are always inherited together, so they act as a single genetic factor. Around 26% of European and up to 45% of African descendants have minor alleles (&ldquo;A&rdquo; and &ldquo;G&rdquo;, respectively). The available data for rs12138950 is incomplete, but it has a similar allele distribution like the previous two SNPs.</span></p> <p><span style="font-weight: 400;">For rs10917477, up to 81% of people of European ancestry carry the &ldquo;A&rdquo; allele. Its frequency in other populations goes up to 93%, with a significant proportion of people carrying both copies.</span></p> <h2><strong>Recommendations to Support the Thyroid</strong></h2> <p><span style="font-weight: 400;">There isn&rsquo;t a known way to prevent hypothyroidism, but doctors can successfully treat it with medications once diagnosed.</span></p> <p><span style="font-weight: 400;">Low thyroid hormones can manifest with fatigue, a pale and puffy face, weight gain, and intolerance to cold exposure. If you think you may be experiencing any of these symptoms, it's essential to consult with your doctor to ensure you get adequate medical care [</span><a href="https://www.mayoclinic.org/diseases-conditions/hashimotos-disease/symptoms-causes/syc-20351855"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In the following sections, we'll discuss some lifestyle, diet, and supplement choices that may help alongside standard treatment. However, keep in mind that these complementary approaches should not replace conventional treatment &mdash; and always be sure to discuss any significant lifestyle changes or new supplements with your doctor first!</span></p> <p><strong>*9349364707020942*</strong></p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Cold Exposure</strong></h4> <p><a href="https://selfhacked.com/blog/12-reasons-embrace-cold/"><span style="font-weight: 400;">Cold exposure</span></a><span style="font-weight: 400;"> stimulates brown fat/adipose tissue (BAT) to produce thyroid hormones. Consequently, BAT supports fat burning and energy production [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/14715917"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486781/"><span style="font-weight: 400;"> R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726172/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The body sharply increases cAMP as a metabolic response to cold, which may also diminish the effect of CAPZB variants on the thyroid. In one small clinical trial, acute cold exposure raised blood levels of T3 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1331079/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/2547726"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/2981794"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Cold showers are the easiest way to practice cold exposure all year long and potentially support thyroid health.</span></p> <h4><strong>Avoid Mercury Exposure</strong></h4> <p><a href="https://content.selfdecode.com/heavy-metals-detox/"><span style="font-weight: 400;">Heavy metals</span></a><span style="font-weight: 400;"> such as mercury can contribute to thyroid disorders by increasing thyroid antibodies [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/7704000"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Removal of mercury-containing dental amalgams cut thyroid antibodies in half in 27 people with mercury allergies and thyroid autoimmunity. Other potential sources of mercury include contaminated fish and vaccine adjuvants [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344667/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876573/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16804512"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC128404/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a clinical study of 84 children, mercury increased CAPZB expression; this effect may further impair the balance of thyroid hormones [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006666/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>Diet</strong></h3> <p><span style="font-weight: 400;">Thyroid cells combine thyroglobulin with </span><a href="https://selfhacked.com/blog/health-benefits-iodine-pregnancy-childhood-diet/"><span style="font-weight: 400;">iodine</span></a><span style="font-weight: 400;"> to make the hormones. Iodine deficiency is the leading cause of hypothyroidism in developing countries. Make sure you&rsquo;re getting enough iodine, especially if your CAPZB variants are hindering this process [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049553/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The recommended daily intake of iodine is 150 mcg. Seaweed, seafood, and Iodized salt are the best sources of this nutrient. Dairy products largely contribute to daily iodine intake, especially in western diets, but they may be an issue for sensitive people [</span><a href="https://ods.od.nih.gov/factsheets/Iodine-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">That said, excess iodine can produce opposite effects and contribute to thyroid autoimmunity. Check your iodine levels and never go above the safe upper limit of 1,100 mcg per day [</span><a href="https://ods.od.nih.gov/factsheets/Iodine-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404933/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">To support the thyroid, make sure to maintain adequate iodine levels by getting 150 mcg daily. The best food sources of this nutrient are seaweed, seafood, and Iodized salt.</span></p> <h3><strong>Supplements</strong></h3> <p><em><span style="font-weight: 400;">Please keep in mind that forskolin is still in the investigational phase and hasn&rsquo;t been FDA-approved for any medical condition. Make sure to check with your doctor before supplementing.</span></em></p> <p><a href="https://selfhacked.com/blog/health-benefits-of-forskolin/"><span style="font-weight: 400;">Forskolin</span></a><span style="font-weight: 400;">, a component from the Indian Coleus plant, can boost cAMP and potentially reduce the adverse effects of your CAPZB variants [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991045/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">By increasing cAMP, forskolin may stimulate the secretion of T4 from the thyroid, but clinical research hasn't confirmed this effect [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/2052424"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/6286284"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p>
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83 | content_learn_more_5412265238616791_text == Some of your CAPZB variants may weakly correlate with impaired thyroid function. However, keep in mind that CAPZB is just one of many different genetic factors that can influence thyroid health. Specific lifestyle changes and supplements may help by increasing cAMP and supporting the thyroid — read on to learn more!
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rsIDs = rs10917477,rs12138950,rs1472565,rs10917469,rs10799824
rsStatus = rs10917477,,chr1,19534612,A,C,G,T,31,0,Normal
rsStatus = rs12138950,LOC105376817,chr1,19512621,A,C,,,29,0,Normal
rsStatus = rs1472565,CAPZB,chr1,19428536,T,A,C,G,30,0,Normal
rsStatus = rs10917469,LOC105376817,chr1,19517082,A,G,T,,29,0,Normal
rsStatus = rs10799824,LOC105376817,chr1,19514680,G,A,,,29,0,Normal
