84 | id == 84
84 | category_id == 6
84 | category_order == 4
84 | category_name == Thyroid
84 | category_color == #C47AC0
84 | slug == VAV3-low-thyroid-hormones-Hashimoto
84 | title == The Link Between Immunity and Low Thyroid Hormones (VAV3)
84 | meta_description == VAV3 is involved in immunity control. Click to discover the variants in this gene associated with low thyroid hormones.
84 | summary == <p style="text-align:justify"><strong>The VAV3 gene is crucial in the immune system control and development. Surprisingly, studies have identified different VAV3 variants associated with low thyroid hormones &mdash; read on for the details!</strong></p>
84 | overall_score_text == Your thyroid autoimmunity score (based on VAV3 gene)
84 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ba64d117.jpg
84 | author_id == 9
84 | author_name == Aleksa Ristic
84 | author_title == MS (Pharmacy)
84 | author_order == 45
84 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
84 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
84 | reviewer == None
84 | medical_reviewer_id == 11
84 | medical_reviewer_name == Puya Yazdi
84 | medical_reviewer_title == MD
84 | publish_date == 2020
84 | publish_date == 1
84 | publish_date == 24
84 | avg_rating == 5.0
84 | tags_id == 33
84 | tags_name == Autoimmunity
84 | tags_id == 96
84 | tags_name == Cytokines
84 | tags_id == 48
84 | tags_name == Hashimoto's
84 | tags_id == 43
84 | tags_name == Hypothyroidism
84 | tags_id == 95
84 | tags_name == Immune System
84 | tags_id == 24
84 | tags_name == Inflammation
84 | tags_id == 117
84 | tags_name == Levothyroxine
84 | tags_id == 41
84 | tags_name == Thyroid
84 | tags_id == 205
84 | tags_name == TSH
84 | tags_id == 230
84 | tags_name == VAV3 gene
84 | permissions_favorite == False
84 | permissions_rate == False
84 | content_article == <table style="width: 90%; border-collapse: collapse; margin-left: auto; margin-right: auto;" border="1" cellpadding="10"> <tbody> <tr> <td style="width: 100%;"><strong>Note:</strong>&nbsp;If you're curious to learn more about the many different genetic factors that can influence chronic inflammation&nbsp;&mdash;&nbsp;and what you can potentially do to counteract them&nbsp;&mdash;&nbsp;we highly recommend checking out SelfDecode's&nbsp;<a href="https://get.selfdecode.com/gene-reports/inflammation/" target="_blank" rel="noopener"><strong><em>Inflammation DNA Wellness Report</em></strong></a>, which will you give you personalized analysis of many key inflammation-related genes!</td> </tr> </tbody> </table> <p>&nbsp;</p> <h2><strong>VAV3: Complex Roles in the Immune System</strong></h2> <p><span style="font-weight: 400;">The </span><a href="../../gene/vav3/"><em><span style="font-weight: 400;">VAV3</span></em></a><span style="font-weight: 400;"> gene encodes for a protein (vav 3 guanine nucleotide exchange factor) with versatile regulatory functions in the immune, cardiovascular, and nervous systems. This protein activates specific enzymes that break down GTP, influencing </span><a href="https://content.selfdecode.com/lymphocytes/"><span style="font-weight: 400;">lymphocyte</span></a><span style="font-weight: 400;"> cell replication, activity, and transcription of different genes [</span><a href="https://www.ncbi.nlm.nih.gov/gene/10451"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">VAV3 controls early T cell development and selection in the thymus. The lack of this protein allows for the survival of overactive T cells. On the other hand, overexpressed VAV3 hinders T cell activity and immune response, paving the path for cancer [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Indeed, scientists have observed high levels of VAV3 in different types of cancer, including thyroid cancer [</span><a href="https://www.nature.com/articles/srep09360"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412345/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511346/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The VAV3 gene encodes for a protein that regulates the activity and development of immune cells. It ensures a balanced immune response, and excess levels are potentially associated with cancer formation.</span></p> <h2><strong>VAV3 and Thyroid Health</strong></h2> <p><span style="font-weight: 400;">Although scientists are still researching the roles of VAV3 in thyroid health, they have already identified different variants in this gene associated with thyroid function.</span></p> <h3><strong>Hypothyroidism</strong></h3> <p><span style="font-weight: 400;">A study of nearly 40,000 Caucasian (European) subjects looked to determine the main genetic variants that correlate with low </span><a href="https://content.selfdecode.com/thyroid-hormones-t4t3/"><span style="font-weight: 400;">thyroid hormones</span></a><span style="font-weight: 400;">. Surprisingly, one VAV3 variant&mdash;</span><a href="../../snp/rs4915077/"><span style="font-weight: 400;">rs4915077</span></a><span style="font-weight: 400;">&mdash; showed a strong correlation: people with the &ldquo;C&rdquo; allele had 30% higher rates of hypothyroidism [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321023/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a smaller clinical trial of 4,200 Asian participants, </span><a href="../../snp/rs12126655/"><span style="font-weight: 400;">rs12126655</span></a><span style="font-weight: 400;"> showed a significant association with TSH, a measure of thyroid function. The "G" allele carriers had significantly higher TSH levels and were more likely to have subclinical hypothyroidism. The authors stated insufficient sample size as a significant limitation of this study [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103676/?report=classic"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In subclinical hypothyroidism, </span><a href="https://content.selfdecode.com/thyroid-stimulating-hormone/"><span style="font-weight: 400;">TSH levels</span></a><span style="font-weight: 400;"> are slightly increased while T4 is in the normal range. It occurs in about 4% of the US population [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21841780/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">According to extensive genetic studies, VAV3 variants&mdash;rs4915077 and&nbsp; rs12126655&mdash;are associated with increased TSH and hypothyroidism.</span></p> <h3><strong>Autoimmune Background</strong></h3> <p><span style="font-weight: 400;">VAV3 doesn&rsquo;t play a direct role in thyroid function or development. Based on its physiological roles in the immune response, a group of scientists has suggested an autoimmune background of VAV3-associated hypothyroidism [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203810/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In support of this claim, a Japanese trial of 1,800 subjects has found a robust association between one VAV3 variant&mdash;</span><a href="../../snp/rs7537605/"><span style="font-weight: 400;">rs7537605</span></a><span style="font-weight: 400;">&mdash;and </span><a href="https://content.selfdecode.com/hashimotos/"><span style="font-weight: 400;">Hashimoto&rsquo;s disease</span></a><span style="font-weight: 400;"> (autoimmune hypothyroidism). Those with at least one copy of the &ldquo;A&rdquo; allele had 60% higher rates of HD [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25429627"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In theory, the above SNPs may reduce VAV3 expression and thus allow for the development of auto-reactive T cells. On the other hand, the opposite allele on </span><span style="font-weight: 400;">rs4915076 (T) increases VAV3 expression in the thyroid and correlates with certain forms of thyroid cancer [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511346/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021315/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Still, the exact mechanisms VAV3-associated changes in thyroid function are yet to be determined.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">VAV3-associated hypothyroidism may have an autoimmune background. One variant, rs7537605, is associated with Hashimoto&rsquo;s disease in Japanese people.</span></p> <h2><strong>Your VAV3 Results for Low Thyroid Hormones</strong></h2> <p><em><span style="font-weight: 400;">You can see your genotype for several </span><span style="font-weight: 400;">VAV3</span><span style="font-weight: 400;"> SNPs in the table below. However, note that these variants are just associated with some aspects of thyroid health. That does not mean they will necessarily make you more prone to thyroid disorders! More research will be needed to determine whether and how much they contribute to the actual development of thyroid autoimmunity.</span></em></p> <p><strong>*2055490281529999*</strong></p> <p><strong>Primary SNPs:</strong></p> <p><strong><em>VAV3</em></strong> <a href="../../snp/rs4915077/"><strong>rs4915077</strong></a><span style="font-weight: 400;">:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;T&rdquo; doesn&rsquo;t correlate with hypothyroidism</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;C&rdquo; correlates with higher rates of hypothyroidism</span></li> </ul> <p><strong><em>VAV3</em></strong> <a href="../../snp/rs12126655/"><strong>rs12126655</strong></a><span style="font-weight: 400;">:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;A&rdquo; doesn&rsquo;t correlate with hypothyroidism</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;G&rdquo; correlates with subclinical hypothyroidism</span></li> </ul> <p><strong><em>VAV3</em></strong> <a href="../../snp/rs7537605/"><strong>rs7537605</strong></a><span style="font-weight: 400;">:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;G&rdquo; doesn&rsquo;t correlate with Hashimoto&rsquo;s disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;A&rdquo; correlates with higher rates of Hashimoto&rsquo;s disease</span></li> </ul> <p><strong>*2006224461458967*</strong></p> <h3><strong>Population Frequency</strong></h3> <p><span style="font-weight: 400;">About 13% of European descendants carry the &ldquo;C&rdquo; allele on rs4915077. This allele is more common in East Asian populations, with about 50% of people having at least one copy.</span></p> <p><span style="font-weight: 400;">For the other two SNPs, rs12126655 and rs7537605, around 40% of the general population carry one copy of &ldquo;problematic&rdquo; alleles (&ldquo;G&rdquo; and &ldquo;A&rdquo;, respectively) and around 10% carry both copies. These alleles are a bit less common among South Asian descendants (e.g. India).</span></p> <h2><strong>Recommendations to Support the Thyroid</strong></h2> <p><span style="font-weight: 400;">There isn&rsquo;t a known way to prevent hypothyroidism, including Hashimoto&rsquo;s disease (HD), but doctors can successfully treat it with medications once diagnosed.</span></p> <p><span style="font-weight: 400;">Low thyroid hormones can manifest with fatigue, a pale and puffy face, weight gain, and intolerance to cold temperatures. If you think you may be experiencing any of these symptoms, it's essential to consult with your doctor to ensure you get adequate medical care [</span><a href="https://www.mayoclinic.org/diseases-conditions/hashimotos-disease/symptoms-causes/syc-20351855"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In the following sections, we'll detail some lifestyle, diet, and supplement choices that may help alongside standard treatment. However, keep in mind that these complementary approaches should not replace conventional medical treatment &mdash; and always be sure to discuss any significant lifestyle changes or new supplements with your doctor first!</span></p> <p><strong>*6461703611713395*</strong></p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Heavy Metals</strong></h4> <p><a href="https://selfhacked.com/blog/heavy-metals-detox/"><span style="font-weight: 400;">Heavy metals</span></a><span style="font-weight: 400;">, such as mercury and cadmium, can contribute to VAV3-related thyroid disorders, namely Hashimoto's disease (HD), by increasing thyroid antibodies [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/7704000"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Mercury ions over-activate T cells and spike inflammatory IL-17 in exposed humans and animals, which may worsen the effects of discussed VAV3 variants [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787652/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Removal of mercury-containing dental amalgams cut thyroid antibodies in half in 27 people with mercury allergies and thyroid autoimmunity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16804512"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a study of over 5,600 Chinese adults, women exposed to more cadmium had higher </span><a href="https://content.selfdecode.com/thyroglobulin/"><span style="font-weight: 400;">thyroglobulin</span></a><span style="font-weight: 400;"> antibody levels, observed in most HD patients. Sources of cadmium exposure include cigarette smoke, processed and instant foods, and contaminated large ocean fish [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28667913"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Therefore, avoiding exposure to heavy metals sources &mdash; such as cigarette smoke, air and water pollution, batteries, paints, some plastics, processed foods, and contaminated ocean fish &mdash; may preserve your thyroid health [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28667913"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056571/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Check out our </span><a href="https://content.selfdecode.com/heavy-metals-detox/"><span style="font-weight: 400;">list of safe and proven ways to detox heavy metals</span></a><span style="font-weight: 400;">.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Heavy metals may contribute to VAV3-associated autoimmune hypothyroidism. Make sure to avoid mercury and cadmium exposure, and consider doing a heavy metal detox.</span></p> <h3><strong>Diet</strong></h3> <p><em><span style="font-weight: 400;">Please note that the regulatory bodies haven't approved dietary approaches discussed below when it comes to thyroid disorders. Speak with your doctor before making any major dietary and lifestyle changes!</span></em></p> <h4><strong>Elimination Diets</strong></h4> <h5><strong>Gluten</strong></h5> <p><span style="font-weight: 400;">Autoimmune hypothyroidism and celiac disease often go hand-in-hand. The most common autoimmune condition associated with non-celiac gluten sensitivity (NCGS) is Hashimoto&rsquo;s disease [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27256300"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18611971"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897856/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In patients with celiac disease, gluten can increase T cell reactivity and the levels of inflammatory molecules (</span><a href="https://selfhacked.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/"><span style="font-weight: 400;">TNF-&alpha;</span></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/interleukin-6/"><span style="font-weight: 400;">IL-6</span></a><span style="font-weight: 400;">, and </span><a href="https://selfhacked.com/blog/interleukin-1/"><span style="font-weight: 400;">IL-1b</span></a><span style="font-weight: 400;">). The above VAV3 variants may also contribute to overactive T cells, making this combination particularly dangerous [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705319/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866307/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">According to a trial study in 34 women with autoimmune thyroid disease (AITD), a gluten-free diet reduced the levels of antibodies and resulted in mild clinical improvements. However, it had no apparent benefits for the thyroid in 27 adults with AITD and celiac disease [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22126672"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h5><strong>Soy Isoflavones</strong></h5> <p><span style="font-weight: 400;">In iodine-deficient individuals with hypothyroidism, soy isoflavones (genistein and daidzein) may further impair thyroid function. People with discussed genetic variations should pay special attention as genistein reduced VAV3 expression in one cell-based study [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16571087"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914796/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">That said, soy isoflavones aren&rsquo;t likely to cause trouble in healthy people with adequate iodine levels.</span></p> <h5><strong>Lectins</strong></h5> <p><span style="font-weight: 400;">Dietary lectins may worsen inflammation in people sensitive to them. For example, lectins contributed to autoimmunity in one study with rheumatoid arthritis patients. Preliminary research suggests that avoiding lectins may reduce the symptoms of autoimmune conditions in sensitive individuals [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10884708"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25599185"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Still, more research is needed to clarify the possible connection between lectins and autoimmunity in humans.</span></p> <p><span style="font-weight: 400;">Elimination diets such as the </span><a href="https://selfhack.com/blog/elimination-diet-safest-foods-people-sensitive-everything/"><span style="font-weight: 400;">Lectin Avoidance Diet</span></a><span style="font-weight: 400;"> may help identify common food irritants &mdash; such as lectins and gluten &mdash; that may be worsening autoimmunity in sensitive individuals. Therefore, it might be worth giving a diet like this a test-run for a month or two to see how your body reacts [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10884708"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25599185"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647120/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Certain dietary compounds, such as gluten or lectins, may contribute to VAV3-associated hypothyroidism in sensitive people. Elimination diets may help identify these food sensitivities, although their therapeutic potential is not well-researched.</span></p> <h3><strong>Supplements</strong></h3> <p><em><span style="font-weight: 400;">Keep in mind that the FDA hasn't approved the below supplements for the prevention or treatment of thyroid disorders. Always speak with your doctor before trying out any new supplements or treatment options.</span></em></p> <h4><strong>Selenium + Myo-Inositol</strong></h4> <p><span style="font-weight: 400;">Several clinical studies have reported that </span><a href="https://content.selfdecode.com/health-benefits-selenium/"><span style="font-weight: 400;">selenium</span></a><span style="font-weight: 400;"> supplementation improves thyroid function and reduces antibody levels in people with Hashimoto&rsquo;s disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307254/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21094028"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://content.selfdecode.com/myoinositol/"><span style="font-weight: 400;">Myo-inositol</span></a><span style="font-weight: 400;">, often combined with selenium, was particularly effective for autoimmune hypothyroidism in a couple of smaller clinical trials [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30506520"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331475/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><strong>Vitamin B12</strong></h4> <p><span style="font-weight: 400;">In a clinical trial of 116 patients with hypothyroidism, nearly 40% had a </span><a href="https://content.selfdecode.com/blog/vitamin-b12/"><span style="font-weight: 400;">vitamin B12</span></a><span style="font-weight: 400;"> deficiency. Vitamin B12 supplementation improved the symptoms in more than half of these subjects [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18655403"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a study of 110 patients with multiple sclerosis, those with vitamin B12 deficiency had significantly lower thyroid hormones [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009884/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A review of 6 clinical trials confirmed the connection between vitamin B12 deficiency and low thyroid hormones, especially in cases of autoimmune hypothyroidism [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27222404"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Vitamin B12 supplements may help correct a deficiency, which is common in people with autoimmune hypothyroidism. The therapeutic effects of B12 supplements on thyroid function are not well researched.</span></p>
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84 | content_learn_more_2006224461458967_text == Some of your VAV3 variants are weakly associated with low thyroid hormones. However, keep in mind that VAV3 is just one of many different genetic factors that can influence thyroid health. Specific dietary and lifestyle changes may help by reducing thyroid antibodies — read on to learn more!
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rsIDs = rs7537605,rs12126655,rs4915077,rs4915076
rsStatus = rs7537605,VAV3,chr1,107800465,G,A,T,,20,6,HET
rsStatus = rs12126655,VAV3,chr1,107814198,A,C,G,T,19,0,Normal
rsStatus = rs4915077,VAV3,chr1,107823394,T,C,G,,24,0,Normal
rsStatus = rs4915076,VAV3,chr1,107816883,T,A,C,,36,0,Normal
