97 | id == 97
97 | category_id == 9
97 | category_order == 6
97 | category_name == Longevity
97 | category_color == #C47AC0
97 | slug == IL10-Longevity
97 | title == How This Anti-Inflammatory Gene Is Connected To Lifespan (IL10)
97 | meta_description == The IL10 gene plays a key role in the immune response and inflammation. It may also influence lifespan. Learn more here!
97 | summary == <p style="text-align:justify"><strong>The IL10 gene has important anti-inflammatory effects and plays a key role in the immune system. There is also some evidence that this gene may influence longevity. Find out what this gene does and how it affects lifespan.</strong></p>
97 | overall_score_text == Your Longevity Score (Based on IL10 Gene)
97 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/IL10--Longevity.jpg
97 | author_id == 8
97 | author_name == Mathew Eng
97 | author_title == PharmD
97 | author_order == 40
97 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Mathew.jpg
97 | author_intro == <p><strong>Mathew received his PharmD from the University of Hawaii and an undergraduate degree in Biology from the University of Washington.</strong></p>    <p>Mathew is a licensed pharmacist with clinical experience in oncology, infectious disease, and diabetes management. He has a passion for personalized patient care and believes that education is essential to living a healthy life. His goal is to motivate individuals to find ways to manage their chronic conditions.</p>
97 | reviewer == None
97 | medical_reviewer_id == 11
97 | medical_reviewer_name == Puya Yazdi
97 | medical_reviewer_title == MD
97 | publish_date == 2020
97 | publish_date == 2
97 | publish_date == 5
97 | avg_rating == 4.625
97 | tags_id == 96
97 | tags_name == Cytokines
97 | tags_id == 240
97 | tags_name == IL-10
97 | tags_id == 239
97 | tags_name == IL10 gene
97 | tags_id == 95
97 | tags_name == Immune System
97 | tags_id == 24
97 | tags_name == Inflammation
97 | permissions_favorite == False
97 | permissions_rate == False
97 | content_article == <h2><strong>What Is The <em>IL10</em> Gene?</strong></h2> <p><span style="font-weight: 400;">The </span><a href="../../gene/IL10/"><em><span style="font-weight: 400;">IL10</span></em><span style="font-weight: 400;"> gene</span></a><span style="font-weight: 400;"> helps create a protein in the body called </span><strong>IL-10</strong><span style="font-weight: 400;"> (short for interleukin 10) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18424693"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The IL-10 protein has many functions that all center around the immune system and inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410706/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Generally speaking, IL-10 helps suppress compounds that cause inflammation while stimulating certain components of the immune system [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410706/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Research shows that certain variations in the </span><em><span style="font-weight: 400;">IL10</span></em><span style="font-weight: 400;"> gene may predispose individuals to several health conditions, including autoimmune disorders, inflammatory diseases, and infections [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410706/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20509889"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22615793"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">More intriguing, perhaps, are the studies that have found that certain variants of </span><em><span style="font-weight: 400;">IL10</span></em><span style="font-weight: 400;"> may be associated with </span><a href="https://selfhacked.com/blog/lifestyle-diet-increase-longevity/"><span style="font-weight: 400;">longer lifespans</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11857058"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20518833"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>The IL-10 Protein</strong></h3> <p><span style="font-weight: 400;">The IL-10 protein is produced with help from the </span><em><span style="font-weight: 400;">IL10</span></em><span style="font-weight: 400;"> gene. IL-10 belongs to a class of proteins called cytokines, which are involved in cell signaling [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18424693"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Unlike many other cytokines, IL-10 is primarily an anti-inflammatory compound [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18424693"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Some of the functions of IL-10 include [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18424693"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410706/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Blocking inflammatory cytokines, such as TNF&alpha;, IL-1&beta;, and </span><a href="https://www.selfhacked.com/blog/interferon-gamma-how-to-increase-decrease-high-low-levels/"><span style="font-weight: 400;">IFN&gamma;</span></a></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Stimulating the development of T cells, B cells, and antibodies</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Blocking the activity of NF-&kappa;B</span></li> </ul> <p><span style="font-weight: 400;">The IL-10 protein primarily works by limiting the body&rsquo;s immune response to </span><em><span style="font-weight: 400;">pathogens</span></em><span style="font-weight: 400;">. A pathogen is any infectious agent that can cause disease, such as bacteria, viruses, and fungi [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18424693"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410706/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">IL-10 primarily does this by blocking the immune system&rsquo;s ability to recognize pathogens. This prevents the body from triggering an inflammatory response [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18424693"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410706/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">However, this activity is not always beneficial. Excessively blocking the body&rsquo;s ability to recognize pathogens can increase the risk of infection [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18424693"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410706/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The IL-10 protein has many functions, such as suppressing the production of inflammatory compounds while also stimulating the immune system.</span></p> <h2><strong>How Does <em>IL10</em> Affect Lifespan?</strong></h2> <p><span style="font-weight: 400;">There is evidence that the </span><em><span style="font-weight: 400;">IL10</span></em><span style="font-weight: 400;"> gene has a significant impact on lifespan. More specifically, variants of </span><em><span style="font-weight: 400;">IL10</span></em><span style="font-weight: 400;"> that increase the production of IL-10 may be associated with better longevity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15915584"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">How does increasing the production of IL-10 improve longevity?</span></p> <p><span style="font-weight: 400;">According to some researchers, one possible explanation may be the anti-inflammatory effects of IL-10. Increased IL-10 levels may help prevent inflammation-related diseases, which may improve overall survival [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15915584"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Another possible mechanism is the effect of IL-10 on cancer. According to animal studies, increased production of IL-10 may help inhibit tumor growth and suppress the ability of cancers to spread [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15915584"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24778315"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">However, there are still some questions regarding the benefits of increased IL-10 production. For example, high levels of IL-10 can also increase the body&rsquo;s susceptibility to infections, which would negatively affect longevity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18424693"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15915584"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The anti-inflammatory and anti-cancer properties of IL-10 may help explain why certain variants of </span><em><span style="font-weight: 400;">IL10</span></em><span style="font-weight: 400;"> are associated with longer lifespans.</span></span></p> <h2><strong><em>IL10</em> And Longevity</strong></h2> <h3><strong>Supporting Evidence</strong></h3> <p><span style="font-weight: 400;">Research suggests that the </span><em><span style="font-weight: 400;">IL10</span></em><span style="font-weight: 400;"> gene may play a role in longevity. The &lsquo;CC&rsquo; genotype in </span><a href="../../snp/rs1800896/"><strong>rs1800896</strong></a> <span style="font-weight: 400;">(sometimes called IL-10 -1082) appears to be associated with longer lifespans [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20518833"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11857058"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">One study looked at the genetic information of 450 Italian men and women. </span><strong>Researchers found that the &lsquo;CC&rsquo; genotype was significantly more common in men who were 100 years or older</strong><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11857058"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">However, this association between the &lsquo;CC&rsquo; genotype and longevity was </span><em><span style="font-weight: 400;">not</span></em><span style="font-weight: 400;"> present in women [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11857058"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A follow-up study of 401 men and women (also from Italian populations) revealed similar results. The &lsquo;CC&rsquo; genotype was much more common in men who lived exceptionally long lives, but there appears to be no effect in women [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12676903"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The &lsquo;CC&rsquo; genotype in rs1800896 may be linked to longer lifespans. However, this association has only been found in Italian men.</span></p> <h3><strong>Conflicting Evidence</strong></h3> <p><span style="font-weight: 400;">Not all studies have found evidence that the </span><em><span style="font-weight: 400;">IL10</span></em><span style="font-weight: 400;"> gene influences longevity.</span></p> <p><span style="font-weight: 400;">For example, several studies have shown no link between rs1800896 and longer lifespans. This includes research that has examined Finnish, Irish, and Sardinian populations [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11640949"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12633940"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15462469"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">On top of that, one study suggests that the &lsquo;T&rsquo; allele (rather than the &lsquo;C&rsquo; allele) may be more common in those that have longer lifespans, based on data taken from a Jordanian population [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20518833"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Several studies suggest the &lsquo;CC&rsquo; genotype may not be associated with longevity, based on results from Finnish, Irish, Sardinian, and Jordanian populations.</span></p> <h2><strong>Your <em>IL10</em> Results for Longevity</strong></h2> <p><em><span style="font-weight: 400;">You can see your genotype for IL10 in the table below. However, keep in mind that these associations are based on studies from certain ethnic populations &mdash; so you should interpret your results with caution if you are not descended from one of these specific groups!</span></em></p> <p>*8489999534804515*</p> <p><strong>Primary SNP:&nbsp;</strong></p> <p><a href="../../gene/IL10/"><strong>IL10</strong></a> <a href="../../snp/rs1800896/"><strong>rs1800896</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;CT&rsquo; and 'TT' = No association with longevity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;CC&rsquo; = More common in those with longer lifespans in certain populations</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The association between the &lsquo;CC&rsquo; genotype and longevity has only been found in Italian men</span></li> </ul> <p><span style="font-weight: 400;">*7851753284734695*</span></p> <h3><strong>Frequency in Population</strong></h3> <p><span style="font-weight: 400;">In general, the &lsquo;T&rsquo; allele is much more common than the &lsquo;C&rsquo; allele. However, the frequencies of these alleles can vary depending on ethnicity.</span></p> <p><span style="font-weight: 400;">For example, about 24% of people of European descent have the &lsquo;CC&rsquo; genotype.&nbsp;</span></p> <p><span style="font-weight: 400;">On the other hand, only about 1% of Eastern Asians have the &lsquo;CC&rsquo; genotype.</span></p> <h2><strong>Recommendations For Longevity</strong></h2> <p><em><span style="font-weight: 400;">Before implementing any of the following strategies, always speak with your doctor first about your options! There may be unexpected interactions with your current medications or health conditions.&nbsp;</span></em></p> <p><em><span style="font-weight: 400;">Also keep in mind that none of these recommendations should ever be used to replace any of the treatments or medications that your doctor gives you.</span></em></p> <p>*1051728470994717*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Exercise</strong></h4> <p><span style="font-weight: 400;">Regular </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> is a great way to </span><a href="https://selfhacked.com/blog/natural-approaches-to-lower-inflammation-decrease-granulocytes/"><span style="font-weight: 400;">reduce inflammation</span></a><span style="font-weight: 400;">, stimulate the immune system, and improve longevity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243532/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320801/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Physical activity can increase the level of IL-10 in the blood, which contributes to the anti-inflammatory effect of exercise [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30536945"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20594330"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Research suggests that exercise duration stimulates IL-10 activity more than exercise intensity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30536945"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Regardless of IL-10 status, research consistently shows that regular physical activity (at least 150 minutes of moderate aerobic exercise each week) is one of the best ways to </span><a href="https://selfhacked.com/blog/lifestyle-diet-increase-longevity/"><span style="font-weight: 400;">increase lifespan</span></a><span style="font-weight: 400;"> and quality of life [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23063021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28943267"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501820/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><strong>Controlling Metabolic Syndrome</strong></h4> <p><span style="font-weight: 400;">A patient may be diagnosed with metabolic syndrome if they have at least 3 of the following health conditions [</span><a href="https://www.nhlbi.nih.gov/health-topics/metabolic-syndrome"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Central obesity (increased abdominal fat)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">High blood pressure</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">High blood sugar</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">High </span><a href="https://www.selfhacked.com/blog/triglycerides/"><span style="font-weight: 400;">triglycerides</span></a></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Low </span><a href="https://www.selfhacked.com/blog/hdl-cholesterol/"><span style="font-weight: 400;">HDL</span></a><span style="font-weight: 400;"> (the &ldquo;good&rdquo; </span><a href="https://www.selfhacked.com/blog/cholesterol/"><span style="font-weight: 400;">cholesterol</span></a><span style="font-weight: 400;">)</span></li> </ul> <p><span style="font-weight: 400;">According to clinical research, those with metabolic syndrome typically have lower levels of IL-10 and other anti-inflammatory cytokines [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26816492"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12629085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24467774"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In addition, metabolic syndrome and some of its individual components have been associated with a higher risk of death [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15677798"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19194692"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Controlling the individual components of metabolic syndrome can potentially restore IL-10 activity and may ultimately improve longevity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365955/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">If you suspect you may have metabolic syndrome, speak with your doctor to learn more about your treatment options.</span></p> <h3><strong>Supplements</strong></h3> <p><em><span style="font-weight: 400;">There&rsquo;s some evidence that certain supplements may help improve IL10 function and possibly contribute to longevity. However, most of this research is based on animal and cell models &mdash; their effect in humans is not always clear.</span></em></p> <p><em><span style="font-weight: 400;">Speak with your doctor before using any supplements. These recommendations should never be used to replace any of the treatments or medications that your doctor gives you.</span></em></p> <h4><strong>Probiotics</strong></h4> <p><span style="font-weight: 400;">Research is discovering more and more that the bacteria in the human gut (also known as gut flora or </span><a href="https://selfhacked.com/blog/how-your-gut-microbiota-can-make-you-fat-or-thin/"><span style="font-weight: 400;">gut microbiota</span></a><span style="font-weight: 400;">) has a significant impact on the immune system and health [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104162/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23079287"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Interestingly enough, studies have found that certain strains of </span><a href="https://selfhacked.com/blog/a1probiotics-good-bacteria/"><span style="font-weight: 400;">probiotics</span></a><span style="font-weight: 400;"> can stimulate the production of cytokines, including IL-10 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168568/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">According to human studies, the following probiotics may increase the expression of </span><em><span style="font-weight: 400;">IL10</span></em><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168568/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Bifico, a specific mixture of bacteria containing </span><em><span style="font-weight: 400;">Enterococcus faecalis</span></em><span style="font-weight: 400;">, </span><em><span style="font-weight: 400;">Bifidobacterium longum</span></em><span style="font-weight: 400;">, and </span><a href="https://selfhacked.com/blog/l-acidophilus/"><em><span style="font-weight: 400;">Lactobacillus acidophilus</span></em></a></li> </ul> <ul> <li style="font-weight: 400;"><em><span style="font-weight: 400;">Lactobacillus casei</span></em></li> </ul> <ul> <li style="font-weight: 400;"><em><span style="font-weight: 400;">Lactobacillus salivarius</span></em></li> </ul> <p><span style="font-weight: 400;">It&rsquo;s less clear how </span><a href="https://selfhacked.com/blog/probiotics-healthy-aging/"><span style="font-weight: 400;">probiotics may influence longevity</span></a><span style="font-weight: 400;">, due to a lack of research.&nbsp;</span></p> <p><span style="font-weight: 400;">There is some clinical evidence that probiotics may contribute to longevity by reducing inflammation and helping prevent autoimmune and inflammatory diseases [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23079287"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104162/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A number of animal studies also suggest that the use of probiotics can increase lifespan. However, this is only based on research performed in certain species of flies and worms [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29849035"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376353/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28622510"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">For more ways to increase IL10, </span><a href="https://selfhack.com/blog/il-10/"><span style="font-weight: 400;">read this blog post</span></a><span style="font-weight: 400;">.</span></p>
97 | content_snp_table_8489999534804515_key == 8489999534804515
97 | content_snp_table_8489999534804515_blur == True
97 | content_snp_table_8489999534804515_hidden == False
97 | content_learn_more_7851753284734695_key == 7851753284734695
97 | content_learn_more_7851753284734695_blur == True
97 | content_learn_more_7851753284734695_hidden == False
97 | content_learn_more_7851753284734695_text == Based on the variants we looked at, your IL10 genotype is somewhat associated with longevity in certain ethnic groups. However, this doesn't necessarily reflect your overall longevity — just one gene related to it. Lifestyle changes and supplements can help. Keep scrolling to find out more.
97 | content_recommendation_1051728470994717_key == 1051728470994717
97 | content_recommendation_1051728470994717_blur == True
97 | content_recommendation_1051728470994717_hidden == False
rsIDs = rs1800896
rsStatus = rs1800896,IL10,chr1,206773552,T,C,,,22,9,HET
