98 | id == 98
98 | category_id == 9
98 | category_order == 6
98 | category_name == Longevity
98 | category_color == #C47AC0
98 | slug == gpx1-longevity
98 | title == A Link Between Antioxidant Enzymes and Aging (GPX1)
98 | meta_description == Glutathione peroxidase is an enzyme that may help delay aging and age-related disease. Learn more about this antioxidant here.
98 | summary == <p><strong>Glutathione peroxidase is an antioxidant enzyme that may help delay aging and age-related diseases like cancer, cardiovascular disease, and rheumatoid arthritis. Read on to learn why researchers are investigating the variants in this gene.</strong></p>
98 | overall_score_text == Longevity Score (based on GPX1)
98 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/GPX1.jpg
98 | author_id == 1
98 | author_name == Jasmine Foster
98 | author_title == BSc, BEd
98 | author_order == 36
98 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
98 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
98 | reviewer == None
98 | medical_reviewer_id == 11
98 | medical_reviewer_name == Puya Yazdi
98 | medical_reviewer_title == MD
98 | publish_date == 2020
98 | publish_date == 2
98 | publish_date == 6
98 | avg_rating == 5.0
98 | tags_id == 179
98 | tags_name == Age-Related Disease
98 | tags_id == 78
98 | tags_name == Glutathione
98 | tags_id == 255
98 | tags_name == GPX1 Gene
98 | tags_id == 101
98 | tags_name == Longevity
98 | tags_id == 39
98 | tags_name == Oxidative Stress
98 | tags_id == 44
98 | tags_name == Selenium
98 | permissions_favorite == False
98 | permissions_rate == False
98 | content_article == <h2><span style="font-weight: 400;">What is Glutathione Peroxidase 1?</span></h2> <p><span style="font-weight: 400;">Glutathione peroxidase 1 (GPx) is one of the body&rsquo;s antioxidant enzymes. After the superoxide dismutase (SOD) enzymes convert superoxide into hydrogen peroxide and oxygen, GPx converts hydrogen peroxide and glutathione into glutathione disulfide and water [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751926/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">This entire process gradually converts superoxide (one of the strongest reactive oxygen species) to less and less harmful compounds. GPx is responsible for the final step [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751926/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><span style="font-weight: 400;">Oxidative Stress and Aging</span></h2> <p><span style="font-weight: 400;">Oxidative stress is broadly implicated in aging and age-related diseases, with many researchers outright attributing aging to a deterioration of the body&rsquo;s antioxidant defenses. This is a controversial and contested topic in the study of longevity, but it&rsquo;s fairly clear that oxidative stress plays some kind of role in aging [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927356/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">As such, researchers are very interested in the genes that code for antioxidant enzymes, including </span><em><span style="font-weight: 400;">GPX1</span></em><span style="font-weight: 400;">.</span></p> <h3><span style="font-weight: 400;">How Does Oxidative Stress Make Us Age?</span></h3> <p><span style="font-weight: 400;">According to some research, oxidative stress accumulates and worsens as we age, possibly because of a deterioration of our natural antioxidant defenses (including GPx). Increased oxidative stress opens the door for DNA damage and cell death, which in turn can lead to tissue damage and diseases from cancer to Alzheimer&rsquo;s [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16430879"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551541/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840676/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Some researchers have suggested that this process is enough to account for aging and age-related disease. At the very least, oxidative stress appears to accelerate the process of aging.</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Oxidative stress may contribute to DNA damage, cell death, and age-related disease. Glutathione peroxidase (GPx) is one of our most important antioxidant enzymes.</span></p> <h2><span style="font-weight: 400;">The Role of Glutathione</span></h2> <p><span style="font-weight: 400;">Glutathione is sometimes called the &ldquo;mother of all antioxidants&rdquo; because of how essential it is for the body&rsquo;s antioxidant defenses. It is made of three amino acids &mdash; glutamic acid, cysteine, and glycine &mdash; and it plays a central role in the function of glutathione peroxidase, which uses it to convert hydrogen peroxide to water [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696075/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628138/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Glutathione levels decrease in the human body as we age, and low glutathione levels have been linked to cognitive decline, age-related disease, and general mortality among the elderly [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756154/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005830/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">Glutathione Peroxidase &amp; Longevity</span></h3> <p><span style="font-weight: 400;">One study found a direct link between a common GPX1 variant and human longevity. According to a cohort of elderly Danish people born in 1905, the heterozygous genotype &lsquo;AG&rsquo; at rs1050450 was significantly more common in the very elderly than in the general population. The authors of the study suggested there could be some kind of survival benefit for the &lsquo;AG&rsquo; genotype, but they did not speculate as to why the heterozygote might have an advantage over &lsquo;AA&rsquo; and &lsquo;GG&rsquo; [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720516/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">That said, other studies and other researchers have strongly suggested that the &lsquo;G&rsquo; allele at rs1050450 confers higher GPx activity than the &lsquo;A&rsquo; allele, and that higher GPx activity is associated with better health outcomes [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21185702"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316745/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The heterozygous genotype &lsquo;AG&rsquo; at rs1050450 is more common in very elderly Danish people than in the general population, suggesting a possible survival advantage. Generally, the &lsquo;G&rsquo; allele produces a more efficient enzyme.</span></p> <h3><span style="font-weight: 400;">GPX1 Variants &amp; Disease</span></h3> <p><span style="font-weight: 400;">Multiple </span><em><span style="font-weight: 400;">GPX1 </span></em><span style="font-weight: 400;">variants have been associated with various diseases that can significantly shorten a person&rsquo;s life.&nbsp;</span></p> <p><span style="font-weight: 400;">Three </span><em><span style="font-weight: 400;">GPX1</span></em><span style="font-weight: 400;"> (rs1050450, rs3448, and rs1800668) have been linked to cancer so far. People with the &lsquo;A&rsquo; alleles of rs1050450 and rs1800668 developed prostate cancer and brain tumors at higher rates than those with the &lsquo;G&rsquo; alleles, according to multiple studies. These two SNPs are closely linked, and if you have the &lsquo;A&rsquo; allele at one, you very likely also have the &lsquo;A&rsquo; at the other. Meanwhile, the &lsquo;CC&rsquo; genotype at rs3448 was associated with prostate cancer in another study [</span><a href="https://www.karger.com/?DOI=10.1159/000346279"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750838/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666247/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859305/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Three SNPs, rs1050450 (the &lsquo;A&rsquo; allele), rs1800668 (the &lsquo;A&rsquo; allele) and rs3811699 (the &lsquo;C&rsquo; allele), have also been associated with Kashin-Beck disease (KBD), a bone disease that causes arthritis-like joint pain, enlarged joints, and decreased range of motion. People with KBD tend to have significantly higher oxidative stress and significantly lower selenium than average, suggesting that the disease could be caused (at least in part) by poor GPx activity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751926/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.oarsijournal.com/article/S1063-4584(13)00905-9/fulltext"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The &lsquo;A&rsquo; allele of rs1800668 was also associated with rheumatoid arthritis in Pakistani people [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103134/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Finally, the &lsquo;A&rsquo; allele of rs1050450 was associated with cardiovascular disease in a meta-analysis of eight studies in East Asian populations. The influence of the &lsquo;A&rsquo; allele was considered small, but significant, especially in light of the potential lethality of cardiovascular disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076455/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Multiple </span><em><span style="font-weight: 400;">GPX1</span></em><span style="font-weight: 400;"> SNPs have been associated with age- and oxidative stress-related diseases like cancer, Kashin-Beck disease, rheumatoid arthritis, and cardiovascular disease.</span></span></p> <h2><span style="font-weight: 400;">Your GPX1 Results for Longevity</span></h2> <p><span style="font-weight: 400;">The following SNPs have been linked either directly to longevity or to life-threatening diseases, but current research is limited, and the data is incomplete. Future research may produce opposite findings, and the effect of any particular SNP may be limited to a single ethnic group. Use caution when interpreting your results.</span></p> <p>*9802656586768825*</p> <h3><span style="font-weight: 400;">SNP Summary and Table</span></h3> <p><strong>GPX1 rs1050450</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with cardiovascular disease, Kashin-Beck disease, some cancers, and lower GPx activity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with higher GPx activity (AG higher than GG)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The heterozygous &lsquo;AG&rsquo; genotype is more common in exceptionally long-lived Danish people</span></li> </ul> <p><strong>GPX1 rs3448</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with prostate cancer (CC genotype)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with prostate cancer</span></li> </ul> <p><strong>GPX1 rs180068</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with increased rates of prostate cancer &amp; brain tumors</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with cancer</span></li> </ul> <p><strong>GPX1 rs3811699</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with Kashin-Beck disease and increased oxidative stress</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with lower oxidative stress</span></li> </ul> <p><strong>GPX1 rs8179164</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with higher GPX1 activity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with average GPX1 activity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Only 1.5% of people in the world have a copy of the &lsquo;A&rsquo; allele, which is slightly more common (5.4%) among Europeans and almost nonexistent in Africans and Asians.</span></li> </ul> <p>*6289509587133355*</p> <h2><span style="font-weight: 400;">Recommendations to Increase Longevity</span></h2> <p><span style="font-weight: 400;">The following strategies and supplements have only limited clinical evidence to support them. Talk to your doctor before making significant changes to your diet, lifestyle, or supplement regimen, and never use any of the following strategies in place of something your doctor recommends or prescribes.</span></p> <p>*1140666554883607*</p> <h3><span style="font-weight: 400;">Lifestyle</span></h3> <p><span style="font-weight: 400;">The glutathione antioxidant mechanism&rsquo;s activity appears to increase after physical exercise. One study found that aerobic exercise increased resting glutathione levels in 80 sedentary adults. Researchers believe that the body uses glutathione during aerobic exercise to support mitochondrial function and delay muscle fatigue; people who are physically fit may have higher glutathione reserves and a more efficient GPx system than those who don&rsquo;t exercise, but this has not been confirmed [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17925621"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4328900/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The relationship between glutathione, GPx, and exercise is still being fleshed out in the research, but physical fitness has also been linked to a longer lifespan [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395188/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Another way to maintain GPx may be simply to get enough sleep: in rats, sleep deprivation significantly reduced brain glutathione. This has not been tested in humans, but it&rsquo;s important to maintain a healthy sleep schedule regardless! Regular sleep patterns have been independently associated with human lifespan [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117056/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067693/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Physical fitness and a regular sleep schedule are both linked to increased glutathione reserves and stronger antioxidant defenses, which may help delay aging.</span></p> <h3><span style="font-weight: 400;">Diet</span></h3> <h4><span style="font-weight: 400;">Selenium</span></h4> <p><span style="font-weight: 400;">Glutathione peroxidase requires selenium to function correctly, and selenium deficiency can cause serious health problems. However, selenium supplementation has been linked to toxicity and chronic disease on a few occasions, so we recommend getting selenium from your diet rather than taking supplements, unless your doctor specifically recommends them [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225252/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964084/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The recommended daily intake of selenium is 55 mcg per day, with a slight increase to 60-70 mcg per day for pregnant and breastfeeding mothers. The best dietary sources include seafood, organ meats, and Brazil nuts. The selenium content of meat varies significantly depending on the level of selenium in the vegetation they eat, so meat raised in selenium-rich Iowa will have more of this mineral than selenium-poor Vermont, for example [</span><a href="https://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">One study found that people with the &lsquo;AG&rsquo; genotype at rs1050450 were more reliant on selenium levels for GPx function than people with the &lsquo;GG&rsquo; genotype. If you have the heterozygous &lsquo;AG&rsquo; genotype for this SNP, you might want to pay special attention to your selenium intake [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316745/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Selenium is required for GPx to work, but both too much and too little selenium can cause adverse health outcomes. Selenium-rich foods like seafood, organ meats, and Brazil nuts are preferable to supplements.</span></p> <h4><span style="font-weight: 400;">Sulfur Amino Acids</span></h4> <p><span style="font-weight: 400;">Sulfur-containing amino acids like cysteine and methionine are used to make glutathione. Furthermore, dietary intake of such amino acids has been directly linked to glutathione levels and inflammation in animal and human models [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16702336"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11842890"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Eating protein-rich foods like meat and eggs is the easiest way to increase your intake of sulfur-containing amino acids. Other dietary sources of sulfur include garlic, onions, and cruciferous vegetables. Sulfur from these sources may also be implicated in glutathione metabolism [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2198910/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Dairy intake is also associated with glutathione levels in humans. Some researchers attribute this link to the high calcium and riboflavin levels in milk [</span><a href="https://academic.oup.com/ajcn/article/101/2/287/4494384"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">On the other hand, some research has indicated that restricting sulfur-containing amino acids could increase longevity. However, this was only demonstrated in lab animals, and data from humans on the subject is lacking [</span><a href="https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(19)30239-7/fulltext"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Sulfur-containing amino acids like cysteine and methionine are used to make glutathione. Protein-rich foods like meat and eggs are the best dietary sources.</span></p> <h3><span style="font-weight: 400;">Supplements</span></h3> <p><span style="font-weight: 400;">Glutathione supplements are available; however, oral glutathione doesn&rsquo;t appear to significantly affect oxidative stress in humans. This may be because of an intestinal enzyme called gamma-glutamyl transpeptidase (GGT), which breaks down glutathione in the small intestine [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162377/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Researchers have been developing alternative delivery systems for glutathione, which may be helpful for people with certain diseases (like Parkinson&rsquo;s, HIV, and diabetes) or undergoing cancer treatment [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162377/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Some of the most promising forms of therapeutic glutathione include:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Liposomal glutathione, which is more easily taken up into the bloodstream [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642835/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389332/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">];</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Sublingual glutathione, which is absorbed under the tongue rather than in the intestine [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536296/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">];</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Inhaled (intranasal) glutathione, which is absorbed in the nose. This delivery technique is used to target the brain as directly as possible [</span><a href="https://linkinghub.elsevier.com/retrieve/pii/S1569-1993(14)00226-4"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516583/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Glutathione supplements are available, but glutathione itself is broken down before it can be absorbed in the gut. Other methods of delivery have produced better results.</span></p>
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98 | content_learn_more_6289509587133355_text == Based on the variants we looked at, your GPX1 gene is associated with average levels of oxidative stress. Strategies to increase glutathione reserves, including exercise and protein-rich foods, may help. Keep scrolling to find out more.
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rsIDs = rs180068,rs1050450,rs1800668,rs3811699,rs3448,rs8179164
rsStatus = rs180068,LINC01497,chr17,69961571,G,A,C,T,70,0,Normal
rsStatus = rs1050450,GPX1,chr3,49357401,G,A,,,22,11,HET
rsStatus = rs1800668,GPX1,chr3,49358324,G,A,,,13,13,HET
rsStatus = rs3811699,RHOA,chr3,49358927,T,C,,,21,17,HET
rsStatus = rs3448,RHOA,chr3,49359318,T,C,G,,8,27,HET
rsStatus = rs8179164,RHOA,chr3,49359851,T,A,,,34,0,Normal
