99 | id == 99
99 | category_id == 9
99 | category_order == 6
99 | category_name == Longevity
99 | category_color == #C47AC0
99 | slug == crp-longevity
99 | title == The Complex Relationship Between CRP and Longevity
99 | meta_description == CRP gene variants may affect longevity by balancing the immune system & chronic inflammation. Find out more here.
99 | summary == <p><strong>C-reactive protein (CRP) levels are a well-known risk factor for heart disease. But what about CRP gene variants? Is there a link between CRP levels, CRP gene variants, and longevity? Read on to find out!</strong></p>
99 | overall_score_text == Longevity Score (based on CRP)
99 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CRP.jpg
99 | author_id == 10
99 | author_name == Biljana Novkovic
99 | author_title == PhD
99 | author_order == 50
99 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Biljana.jpg
99 | author_intro == <p><strong>Biljana received her PhD in Ecological Genetics from Hokkaido University.</strong></p>    <p>Before joining SelfHacked, she was a research scientist with extensive field and laboratory experience. She spent 4 years reviewing the scientific literature on supplements, lab tests and other areas of health sciences. She is passionate about releasing the most accurate science &amp; health information available on topics, and she&#39;s meticulous when writing and reviewing articles to make sure the science is sound. She believes that SelfHacked has the best science that is also layperson-friendly on the web.</p>
99 | reviewer == None
99 | medical_reviewer_id == 11
99 | medical_reviewer_name == Puya Yazdi
99 | medical_reviewer_title == MD
99 | publish_date == 2020
99 | publish_date == 2
99 | publish_date == 6
99 | avg_rating == 4.2
99 | tags_id == 179
99 | tags_name == Age-Related Disease
99 | tags_id == 202
99 | tags_name == Aging
99 | tags_id == 258
99 | tags_name == CRP Gene
99 | tags_id == 257
99 | tags_name == Frailty
99 | tags_id == 134
99 | tags_name == Heart Disease
99 | tags_id == 24
99 | tags_name == Inflammation
99 | tags_id == 101
99 | tags_name == Longevity
99 | permissions_favorite == False
99 | permissions_rate == False
99 | content_article == <h2><span style="font-weight: 400;">What is CRP?</span></h2> <p><span style="font-weight: 400;">CRP, short for C-reactive protein, is an important part of the immune system. It's mainly made in the liver and released into the blood in response to injury, inflammation, and infection [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149169/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">It works as a pattern recognition protein, which means that its job is to recognize and bind invading microbes and damaged or altered (i.e. cancer) cells. In essence, CRP tags microbes and defective cells for destruction so they can be cleared away by white blood cells [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058362/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367411/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149169/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">Once the cause of the disturbance has been taken care of, CRP levels usually drop back to normal. However, when there&rsquo;s chronic low-grade inflammation in the body, CRP levels remain slightly increased [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546477/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">CRP's main role is to tag microbes and damaged or altered cells for destruction. CRP levels increase in the short-term with injury, infection, and inflammation and decrease once the disturbance has been taken care of. CRP levels can remain slightly increased in those with chronic low-grade inflammation.</span></p> <h3><span style="font-weight: 400;">CRP and Heart Disease</span></h3> <p><span style="font-weight: 400;">Scientists have found that higher</span> <span style="font-weight: 400;">CRP levels can help predict the future risk of heart (cardiovascular) disease even in apparently healthy people [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155811/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24840259"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://circ.ahajournals.org/content/109/21_suppl_1/II-11.long"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">You can read more about CRP levels and heart disease risk </span><a href="https://selfhacked.com/blog/c-reactive-protein/"><span style="font-weight: 400;">here</span></a><span style="font-weight: 400;">.</span></p> <p><span style="font-weight: 400;">There are several explanations for this.&nbsp;</span></p> <p><span style="font-weight: 400;">Firstly, we know that CRP levels increase in chronic inflammatory states, such as [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458094/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155811/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">High blood pressure (hypertension)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Obesity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Diabetes</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Heart disease&nbsp;</span></li> </ul> <p><span style="font-weight: 400;">Secondly, CRP can also create inflammation on its own. Scientists have found that CRP can damage blood vessels by increasing the release of inflammatory molecules from white blood cells [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155811/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Finally, CRP can also directly inhibit</span><a href="https://selfhacked.com/blog/insulin-101/"><span style="font-weight: 400;"> insulin</span></a><span style="font-weight: 400;"> signaling and prevent blood sugar from entering the muscles, thereby increasing insulin resistance [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155811/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Scientists have found a link between higher CRP levels and heart disease. Elevated CRP indicates there's chronic inflammation in the body. CRP can also damage blood vessels and increase insulin resistance.&nbsp;</span></p> <h3><span style="font-weight: 400;">CRP and Longevity</span></h3> <p><span style="font-weight: 400;">After establishing CRP's role in heart disease, scientists next looked at the link between CRP and longevity. They found that elevated CRP levels were associated with a higher chance of dying (all-cause mortality), especially due to heart disease (cardiovascular mortality) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28327451"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26761114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">But when it comes to CRP gene variants and longevity, the story gets much more complex.&nbsp;</span></p> <h2><span style="font-weight: 400;">CRP Gene And Longevity</span></h2> <p><span style="font-weight: 400;">Why is the relationship between CRP gene variants and longevity not straightforward?</span></p> <p><span style="font-weight: 400;">For a start, there are many factors that may influence how well someone ages, and how long they can live. Genes likely only have a relatively small effect on overall longevity! For example, it is estimated that less than 10% of the variation in human lifespan is determined by genetics [</span><a href="https://ghr.nlm.nih.gov/primer/traits/longevity"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.genetics.org/content/210/3/1109"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. This 10% refers to the population level and doesn't apply to any single person as an individual: in other words, just because you may have a "bad" genetic variant does not mean your lifespan will get reduced by 10% (and that's 10% of the variance between lifespans, not 10% of a human lifespan).&nbsp;</span></p> <p><span style="font-weight: 400;">Furthermore, studies suggest that there are many (over 100) genes associated with lifespan. However, any single one of these genes generally plays only a very modest and limited role in the overall picture &mdash; and </span><em><span style="font-weight: 400;">CRP</span></em><span style="font-weight: 400;"> is one such gene.</span></p> <p><span style="font-weight: 400;">In addition, while we may be tempted to conclude that lower CRP levels are generally better based on the studies that looked at CRP blood levels. However studies that have looked at SNPs in this gene often disagree.</span></p> <p><span style="font-weight: 400;">Most importantly, we know that lifestyle, dietary, and other non-genetic factors have a greater impact on CRP levels than genetic variants -- which is why actual CRP levels in the blood are predictive when it comes to heart disease but CRP gene variants are not.</span></p> <p><span style="font-weight: 400;">The takeaway here is that lifestyle, dietary, and other non-genetic factors are ultimately way more important when it comes to longevity than genes.</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">CRP gene is only one of a multitude of genes that each play a minor, modest role when it comes to longevity. Furthermore, CRP levels are influenced by lifestyle, dietary, and other non-genetic factors and not just genetic variants. That's why the relationship between CRP gene and longevity is complex.</span></p> <h3><span style="font-weight: 400;">rs1205 and Longevity</span></h3> <p><span style="font-weight: 400;">Take for example a commonly-studied SNPs in the </span><em><span style="font-weight: 400;">CRP</span></em><span style="font-weight: 400;"> gene, </span><a href="../../snp/rs1205/"><strong>rs1205</strong></a> <span style="font-weight: 400;">(also known as the &ldquo;1846 G&gt;A&rdquo; polymorphism). The 'C' allele has been linked with higher and the 'T' allele with lower CRP levels.</span></p> <p><span style="font-weight: 400;">A small study looked at 284 Finish people over the age of 90, and found 'T' carriers, who in theory should have lower CRP levels, were more likely to live longer [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17765290"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. This was more or less expected.</span></p> <p><span style="font-weight: 400;">This was supported by studies which found that:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">'T' seemed protective for heart disease (a meta-analysis of 22 studies) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612795/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">'C' was linked to high blood sugar (a study of 945 siblings from 330 families) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554245/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Elderly with the 'TT' genotype were more likely to have multiple health conditions, compared to those with the 'CC' genotype (a study in over 1.7k Chinese aged 70-84 years)</span> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27016573"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><span style="font-weight: 400;">However, in another study of over 5k people, researchers found that having the 'T' allele was associated with [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17888441-common-variants-in-the-crp-gene-in-relation-to-longevity-and-cause-specific-mortality-in-older-adults-the-cardiovascular-health-study/?from_term=crp+polymorphism+longevity&amp;from_pos=5"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">A lower risk of death from heart disease over the next couple of years&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">A HIGHER risk of mortality that's not associated with heart disease, particularly death from cancer.</span></li> </ul> <p><span style="font-weight: 400;">They found this relationship in blacks but not in whites!</span></p> <p><span style="font-weight: 400;">Furthermore, a study of over 3.7k older Australians found that those with the 'T' variant were more likely to be frail compared to those carrying the 'C' variant (and especially the 'CC' genotype) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22192441"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">] -- and frailty is a known enemy of longevity [</span><a href="https://academic.oup.com/ageing/article/47/5/721/4996982"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A meta-analysis of 21 studies with over 26k people found that the 'TT' genotype was associated with a slightly higher incidence of colon cancer, but lower incidence of breast cancer [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24835491"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Scientists think that the 'T' variant, which is associated with lower CRP levels, may prevent the elderly from mounting an efficient immune response, which is why the 'T' variant has been associated with frailty and mortality that's not due to heart disease [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17888441-common-variants-in-the-crp-gene-in-relation-to-longevity-and-cause-specific-mortality-in-older-adults-the-cardiovascular-health-study/?from_term=crp+polymorphism+longevity&amp;from_pos=5"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22192441"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">According to some studies, the 'T' variant of the rs1205 SNP in the CRP gene has been associated with longevity and lower mortality due to heart disease. However, this variant has also been associated with frailty and higher mortality due to causes other than heart disease.</span></p> <h2><span style="font-weight: 400;">Your CRP Results for Longevity</span></h2> <p><span style="font-weight: 400;">You can see your genotype for several </span><em><span style="font-weight: 400;">CRP</span></em><span style="font-weight: 400;"> SNPs in the table below. However, remember that </span><em><span style="font-weight: 400;">CRP</span></em><span style="font-weight: 400;"> is only one of many genes that together influence longevity, and that its effects are modest at best. It&rsquo;s also important to keep in mind that these results are based on association studies suggesting that certain genetic variants are more common in people with longer lifespans. However, more research will be needed to know what role, if any, these variants play in directly causing certain people to live longer &mdash; so take these results with a grain of salt!</span></p> <p>*6276733938687669*</p> <p><strong><em>CRP</em></strong> <a href="../../snp/rs1205/"><strong>rs1205</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with lower CRP levels, longevity and lower heart disease mortality. However, it's also been associated with higher mortality due to causes other than heart disease and frailty.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with higher CRP levels and higher heart disease mortality. Has been associated with lower risk of frailty and lower mortality due to some types of cancer.</span></li> </ul> <p><span style="font-weight: 400;">Every third person carries the 'T' allele (33%) ('CT' or 'TT' genotype). This allele is more common in East Asians (57%) and less common in Africans (17%).</span></p> <p><strong><em>CRP</em></strong> <a href="../../snp/rs1800947/"><strong>rs1800947</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">'G' = Associated with higher CRP levels and possibly higher mortality and heart disease.&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">'C' = Associated with lower CRP levels.&nbsp;</span></li> </ul> <p><span style="font-weight: 400;">A study of over 900 people with heart failure found that the 'G' allele was associated with a higher risk of dying [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29627531"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Similarly, in over 900 people with heart disease, the 'GG' genotype was associated with further adverse events during the three years of follow up [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27580453"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">However, there are also studies that didn't find a link between this SNP and heart disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003147/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27266621"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The 'G' allele is found in less than 3% of the population. It's slightly more common in East Asians (6%) and Europeans (5%), and less common in Africans (0.2%).&nbsp;</span></p> <p><strong><em>CRP</em></strong> <a href="../../snp/rs11265263/"><strong>rs11265263</strong></a><span style="font-weight: 400;">&nbsp;&nbsp;</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">'A' = Associated with higher CRP and possibly increased mortality.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">'C' = Associated with lower CRP levels.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">'T' = Effect unknown.</span></li> </ul> <p><span style="font-weight: 400;">In a single study of 900 people with heart failure, 'A' allele was associated with higher mortality risk [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29627531"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">'A' variant is found in 9% of people. It's more common in East Asians (20%) and less common in Africans (1%). 'T' variant is extremely rare -- less than 0.1% of people have it.</span></p> <p><span style="font-weight: 400;">*6077151000556251*</span></p> <h2><span style="font-weight: 400;">Recommendations to Balance Immune Response And Inflammation</span></h2> <p><span style="font-weight: 400;">As we discussed above, the effects of the </span><em><span style="font-weight: 400;">CRP </span></em><span style="font-weight: 400;">gene on longevity are modest. Great news is that science suggests that lifestyle, dietary, and other non-genetic factors have a bigger impact on your CRP levels than genetics.</span></p> <p><span style="font-weight: 400;">As always, it&rsquo;s extremely important to keep your doctor informed of any major lifestyle or dietary changes you make! This is because it&rsquo;s important to make sure that they won&rsquo;t have any negative interactions with any current medications, preexisting health conditions, or other important factors that could have significant consequences for your health &mdash; so always discuss these with your doctor first.</span></p> <p>*9592596126491792*</p> <p><span style="font-weight: 400;">If your genetics predisposes you for slightly elevated CRP levels, there are many steps you can take to lower CRP-related chronic inflammation in the body. Better yet, many of these strategies are all associated with increased longevity in general, with a lot of very solid scientific and medical evidence to back them up!</span></p> <p><span style="font-weight: 400;">Several of these strategies can also be used to combat frailty in people who may be genetically predisposed to lower CRP levels, mainly: being active, eating well, and minimizing stress.</span></p> <h3><span style="font-weight: 400;">Lifestyle</span></h3> <p><span style="font-weight: 400;">First, you can work with your doctor to address and improve any underlying health conditions. It's CRP&rsquo;s job is to increase in response to infection, tissue damage and inflammation, and CRP levels should decrease as underlying health conditions improve. For example, good blood sugar control in diabetes is associated with lower CRP levels [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12716818"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;&nbsp;</span></p> <p><span style="font-weight: 400;">Another important step you can take is to exercise regularly. Multiple studies have shown that regular physical activity can help decrease CRP [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546477/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25048075"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22520533"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. Even modest amounts of exercise can make a difference. Scientists have made an estimate that the total energy expenditure needed to lower CRP was 368 &ndash; 1,050 calories/week [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320801/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">If you're overweight or obese, </span><a href="https://selfhacked.com/blog/a-comprehensive-list-of-effective-ways-to-lose-weight/"><span style="font-weight: 400;">weight loss</span></a><span style="font-weight: 400;"> and fat reduction can help reduced CRP levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546477/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304884/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. According to one study, odds of achieving desirable CRP levels more than doubles with 5% loss of total body weight and fat mass [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304884/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Finally, find effective ways of dealing with stress. Studies found that psychological stress increases CRP. </span><a href="https://selfhacked.com/blog/health-benefits-of-yoga/"><span style="font-weight: 400;">Yoga</span></a><span style="font-weight: 400;">, Tai Chi, and Qi Gong are examples of the exercise therapies that integrate moderate physical activity, deep breathing, and</span><a href="https://selfhacked.com/blog/meditation/"><span style="font-weight: 400;"> meditation</span></a><span style="font-weight: 400;"> to promote stress reduction and relaxation. All of them have been found to decrease CRP levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079606/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415519/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18514933"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20973735/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136557/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18543381/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21688163/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528077/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26426148"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24372522"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">Diet</span></h3> <p><span style="font-weight: 400;">Healthier diets have been associated with lower CRP levels.</span> <span style="font-weight: 400;">By healthy we mean diets high in fiber and rich in fruits and vegetables. Western diet and diets high in fat, sugar, and refined grains, on the other hand, increase CRP [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833870/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16276071"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">High dietary fiber intake, in particular, has been associated with lower CRP levels [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24176070"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25002911"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In addition, studies suggest that coffee and green tea consumption may have beneficial effects on CRP levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347755/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17023717"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787671/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20441477"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18844498"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22749178"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130641/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26923508"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">Supplements</span></h3> <p><span style="font-weight: 400;">Research suggests that the following supplements may help decrease CRP levels:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Fiber [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23389112"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25578759"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26764316"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Cocoa and dark chocolate [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22854880"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19005437"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460349/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18806104"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Magnesium [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975661/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24814039"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Omega-3 [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27751666"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715379/"><span style="font-weight: 400;"> R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18348080"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555130/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Vitamin E [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25669317"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25895432"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24575826"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/16-proven-benefits-vitamin-b9-folate-folic-acid/"><span style="font-weight: 400;">Folate</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21179048"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27450552"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24628390"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400;">Remember, always speak to your doctor before taking any supplements, because they may interfere with your health condition or your treatment/medications!</span></p>
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99 | content_learn_more_6077151000556251_text == Based on the variants we looked at, your CRP gene may not affect your longevity. However, remember that CRP is only one of many genes that together account for less than 10% of individual differences in longevity, and a healthy lifestyle is significantly more important when it comes to CRP levels and longevity! Keep scrolling to find out more.
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rsIDs = rs11265263,rs1205,rs1800947
rsStatus = rs11265263,,chr1,159740727,C,A,T,,32,0,Normal
rsStatus = rs1205,CRP,chr1,159712443,C,T,,,38,0,Normal
rsStatus = rs1800947,CRP,chr1,159713648,C,A,G,T,33,0,Normal
